Professor Roland Stocker, leader of the Arterial Inflammation and Redox Biology Group at HRI, has been awarded the 2021 Basic Science Award from the esteemed Society for Free Radical Research-Europe.
As recipient of this prestigious award, Prof Stocker was invited to give the keynote lecture on ‘Arterial redox signalling in the control of blood pressure’ at the Society’s international flagship conference. The lecture encompassed a life-body of work by Prof Stocker since he first coined the concept back in 1987, at the start of his career.
Well established since 1982, the Society for Free Radical Research has regional branches and some 2,500 members around the world to advance knowledge and education in free radical processes, with a focus on industrial and medical importance to benefit the public. The Society for Free Radical Research-Europe promotes a variety of research and offers prizes for areas of research, with the Basic Science Award received by Prof Stocker being awarded to prominent scientists recognised for their key scientific achievements in the field of free radical research or a field with the potential for “cross-fertilisation” with free radical research.
“This research has been quite a collaborative project, and I couldn’t have done it without my past and present laboratory members and the various funding bodies who have provided support along the way,” says Prof Stocker.
Prof Stocker is especially grateful to the National Health & Medical Research Council of Australia for continuous funding of his research over the last three decades.
This research by Prof Stocker and his current and past lab members has produced a significant number of high-profile papers, and part of the work is ongoing under the Microvascular Research Unit at HRI led by Dr Christopher Stanley.
Read more on key publications and recent work by Prof Stocker
- Hydrogen peroxide signalling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation. Nat Commun 2021;12: 6626
- Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation. Nature 2019;566:548–552
- Preparation, validation and use of a vasoactive tryptophan-derived hydroperoxide and relevant control compounds. Nat Protoc 2021;16:3382-3418
- Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biol 2021;46:102127
- Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. Redox Biol 2021;47:102152
- A concurrent multi-omics method to assess metabolic changes associated with atherosclerosis using small amounts of arterial tissue from a single mouse. Analytical Chemistry 2019;91(20):12670-12679
- Inhibition of MPO (myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2019;39:1448–1457
- Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque. Eur Heart J 2018 Sep 14;39(35):3301-3310
- Role of oxidative modifications in atherosclerosis. Physiol Rev 2004 Oct;84(4):1381-478
- Bilirubin is an antioxidant of possible physiological importance. Science 1987;235(4792):1043-1046
